P21WAF1/CIP1、 P16蛋白表达与人脑神经胶质瘤的相关分析

doi:10.3969/j.issn.1004-616x.2005.05.016

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2005, Vol. 17 ›› Issue (5): 311-313.doi: 10.3969/j.issn.1004-616x.2005.05.016

Previous Articles Next Articles

Correlation Analysis Between Expression of P21WAF1/CIP1，P16 Proteins and Human Gliomas

JIANG You-hong;SUI Cheng-guang;MENG Fan-dong;MA Ping;WANG Xiao-hua;DAI Xiao-chun

Institute of Cancer Research of the First Affiliated Hospital of China Medical University，Shenyang 110001，Liaoning,China

Received:2004-05-17 Revised:2004-06-18 Online:2005-09-30 Published:2005-09-30
Contact: JIANG You-hong

Abstract

Abstract: BACKROUND ＆ ATM： To investigate the relationship between glioma malignancy grading and P21WAF1/CIP1, P16 gene expressing levels. MATERIAL AND METHODS： The expression levels of P21WAF1/CIP1 and P16 proteins were detected in 98 cases of brain glioma using SABC immunohistochemical staining. Eight normal brain tissues were used as control. RESULTS： The positive expression rates of P21WAF1/CIP1 and P16 protein in glioma were 58.16％ and 42.86％respectively, anda significant difference was observed between gliomas and control.The expression intensity of P21WAF1/CIP1 and P16 decreased with the gliomas grade increasing. Coexpression of P21WAF1/CIP1 and P16 was found in glioma and normal brain tissues. CONCLUSION： The positive expression rate and coexpression rate of P21WAF1/CIP1 and P16 protein may reflex the malignant grade of glioma in some extent,and they can be as a sensitive index for the gliomas grading.

Key words: gliomas, P21WAF1/CIP1 protein, P16 protein, immunohistochemistry

JIANG You-hong, SUI Cheng-guang, MENG Fan-dong, MA Ping, WANG Xiao-hua, DAI Xiao-chun. Correlation Analysis Between Expression of P21WAF1/CIP1，P16 Proteins and Human Gliomas[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2005, 17(5): 311-313.

[1]	JIAO Wenjing, ZHANG Jinyan, MA Ming, GUO Xiujuan, FENG Junhua, SHAO Junguo, JIAO Wenpeng. Expression and clinical significance of MTDH and FoxM1 in hepatocellular carcinomas [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(5): 349-353,359.
[2]	ZHANG Shimin, ZHAO Ruijun. Expression of protein tyrosine phosphatase receptor J in breast cancer tissues and its relationship with clinical prognosis [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(4): 276-279,285.
[3]	YANG Xiuyuan, PAN Yuelong. Expression of CD10 protein in colorectal carcinomas and its clinical significance [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(5): 344-349.
[4]	HUANG Zhuangcheng, WANG Honghao, SHEN Peilin, LIN Ming'en, HE Xuejun. Expression and clinical significance of Notch signalingrelated proteins in cystitis glandularis and bladder cancer [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(5): 374-377,383.
[5]	YANG Xingxiao, ZOU Naiyi, LI Qiaofang, ZHANG Xueyuan, SONG Heng, LIU Zhikun, MA Ming, SHAN Baoen, ZHU Shuchai. Significance in expression of RNF2 and PCNA proteins in esophageal squamous cancer cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(4): 254-257.
[6]	LI Yang, XING Long, MOHAMMED H, MA Xiaolong, XIE Fuqiang, FENG Zhenghu, CHE Yinfu. Clinicopathological significance of expression of thioredoxin and its reductase-1 in tongue squamous cell carcinoma [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(2): 87-91.
[7]	MA Kun, WU Haoyu, LI Peng, WANG Li, LI Baixiang. Induction of dopaminergic neuron degeneration by atrazine in substantia nigra in adolescent rats [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(4): 251-255.
[8]	LIU Dezhong, CHANG Bo, LIN Feixiang, LI Xuedong. β-catenin expression in hepatocellular carcinoma and its effect on prognosis [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(4): 300-303.
[9]	FENG Shuitu, CHEN Yide, CHEN Yuqiang, LIN Yubiao, ZHENG Wenhui. Differential expression of Gadd45α in Helicobacter Pylori-infected human gastric cancer and clinical significance [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(5): 353-358,392.
[10]	ZHAI Xiaoran, JIANG Mei, ZHAO Xiaoting, GU Meng, YUE Wentao. Clinical significance of PFTK1 expression in human non-small cell lung cancer [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(3): 231-235.
[11]	CHEN Guangcan, HONG Liangli, HUANG Jiexiong, XIE Aosi, GUO Dan, LIU Shuhui. Expression of GST-π and P-gp in gastric cardia cancer and their clinical significance in the Chaoshan high risk area [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(1): 36-40.
[12]	HE Jie, WAN Jinghai, LI Xueji, QIAN Haipeng, MENG Xiaoli, HAO Jiajie, XU Xin, WANG Mingrong. TERT promoter mutation is a potential biomarker for predicting poor outcome in gliomas [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(5): 361-365.
[13]	QIN Jiesheng, HONG Liangli, LIN Xuni, WANG Huige, QIU Qiancheng. Expression and significance of Sema4C in laryngeal squamous carcinoma [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(3): 230-233.
[14]	FANG Shaobin, DENG Xiaoling, CHEN Jun, CHEN Yonghui, XU Mingyan. The expression and clinical relevance of integrin αvβ6 and JunB in oral squamous cell carcinoma [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(3): 234-238,241.
[15]	LAN Yu, LIU Dongdong, LIN Ming'en, HONG Yingkai, HUANG Jiansheng, CHEN Si, HE Xuejun. Expression and clinical significance of silent information regulator 1 in bladder urothelial cell carcinoma [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(2): 125-128.

Correlation Analysis Between Expression of P21WAF1/CIP1，P16 Proteins and Human Gliomas

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments